June 6th, 2010
Eating junk-food can be addictive, and apparently, it causes brain changes that look eerily similar to drug addiction. That’s the message not only from the rapidly fattening waistlines of Americans everywhere, but also from the Johnson and Kenny labs at the Scripps Institute.
Food and drug addiction
The idea that obesity is caused by a compulsive pattern of eating, and that there could be a similarity between such compulsive eating and drug addiction isn’t super new. In fact, Dr. Volkow from NIDA seemed to make research into this association her goal when taking the helm of the addiction research kingdom.
When you think about it, the notion isn’t far-fetched: Drug addicts continue to take drugs, in increasing amounts, even though they’d often like to stop (at some point) and in the face of negative consequences and the common loss of other important life functions (like family, work, etc.). Obese individuals are quite the same, eating more and more food regardless of their desire to adopt a healthier diet and in-spite of ridicule, low self-esteem, and decreased functioning that often accompanies extreme weight gain.
The research by Johnson and Kenny examined whether exposure to the kind of high-fat, super high-calorie foods that floods the junk-food market are responsible for creating food-addicts in a similar way to drugs that alter the brain in ways that make stopping more difficult.
Dopamine, reward, and junk-food
The study took three groups of rats and gave them either the regular chow diet lab animals are used to or the worse kind of birthday party food: bacon, sausage, cheesecake, pound cake, frosting and chocolate. You can imagine the party going on in the rat cages that got to eat that! Of the two groups that got to eat the crazy-fat food, one had unlimited access while the other got to binge for only one hour a day.
The bottom line: Only the rats that got unlimited access to the fat-party food developed compulsive eating habits that resulted in roughly twice the weight gain of the other two groups and the ability to continue eating even in the face of signals for punishment (a light that they were trained to associate with shocks).
When the researchers looked deeper, they found that the brains of these rats suffered a significant reduction in the density of a specific kind of dopamine receptor (D2) in a brain part known as the striatum, the same kind of reduction common in drug addicted people and obese individuals. This receptor type is often thought to be important for regulation of impulses, both physical and otherwise. It therefore makes sense that losing this type of function would cause uncontrollable eating or drug taking.
Are drug- and food-addictions the same?
While this research isn’t saying that compulsive eating, or obesity, are the same as drug addiction, it does strongly suggest that there are common mechanisms in both. More importantly, it reveals a common process that unfolds when over-exposure to the reward, in this case food, occurs. This tells us that there can likely be common pathways to these different addictive disorders, though whether any specific person ended up a food- or drug-addict because of this kind of process is still an open question. I wonder if we’ll see something like this with sex addiction soon…
Johnson and Kenny (2010) Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nature neuroscience, 13, 635-641.
|Posted in: Education, Food
Tags: addictive, Animal research, APA, bacon, Brain, cake, calories, chocolate, compulsion, compulsive, compulsive eating, consequences, D2, dopamine, drug, DSM, eating, fat, food addiction, junk-food, lab, NIDA, obesity, rats, receptor, reward, sex addiction, similar, tolerance, weight gain
June 23rd, 2009
Today, I’ll give a short summary of a few interesting talks I saw at the conference:
- Teenage smoking – Children of mothers who used drugs during pregnancy had abnormal stress hormone levels. When assessed over time, their abnormal stress response was associated with an earlier onset (age of first use) of cigarettes smoking and an increased amount and frequency of smoking cigarettes.
- Childhood trauma and drug use – Children who experienced excessive childhood trauma had altered brain activity (in the Nucleus Accumbens specifically) and showed increased anxiety. This area, which is important for essentially all learning, was differentially activated in a way that correlated with the amount of childhood trauma.
- Marijuana withdrawal and relapse to marijuana use – Marijuana withdrawal, which might soon be added to the APA‘s DSM (in version 5) was characterized as: Increased irritability, restlessness, and misery, reduced sleep quality, sleep duration, and food intake. When tested, restlessness, sleep disturbance, and early wakening were found to be predictors of relapse among participating marijuana users.
|Posted in: Drugs, Education, Marijuana
Tags: addiction research, adolescent drug abuse, APA, childhood trauma, cigarettes smoking, Drug addiction, drug use, DSM, marijuana addiction, marijuana facts, marijuana use, marijuana withdrawal, sleep, teenage smoking